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Paracetamol, also know as Acetaminophen, is an important pharmaceutical API to treat pain and fever. It exists in white crystalline powder, slightly soluble in water, freely soluble in alcohol, very slightly soluble in ether and methylene chloride. 

In market, Paracetamol exists in two types: Paracetamol materials in white crystalline powder & Paracetamol DC tablets (DC90 and DC96) in white granules.

Specification (USP34/BP2011 for Paracetamol powder)

Appearance                                    White crystalline powder

Melting point                                  168~172°C
Water                                             0.5% max.
Total impurities                               0.1% max.
Residue on ignition                          0.1% max.
Chloride                                         0.014% max.
Sulfate                                           0.02% max.
Heavy metals                                 0.001%max.
Free p-aminophenol                        0.005%max.
Limit of P-chloroacetanilide              0.001%max.

Assay(anhydrous basis)                   99.0~101.0%

*Please refer to Certificate of Analysis for detailed specification

Paracetamol is typically used for mild to moderate pain

Fever

Paracetamol is used for reducing fever in people of all ages. The World Health Organization (WHO) recommends that paracetamol be used to treat fever in children only if their temperature is greater than 38.5 °C (101.3 °F).The efficacy of paracetamol by itself in children with fevers has been questioned and a meta-analysis showed that it is less effective than ibuprofen.

Pain

Paracetamol is used for the relief of mild to moderate pain. The use of the intravenous form for pain of sudden onset in people in the emergency department is supported by limited evidence.

Osteoarthritis

The American College of Rheumatology recommends paracetamol as one of several treatment options for people with arthritis pain of the hip, hand, or knee that does not improve with exercise and weight loss. It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin due to concerns with bleeding with aspirin.

Low back pain

Based on a systematic review, paracetamol is recommended by the American College of Physicians and the American Pain Society as a first-line treatment for low back pain. However other systematic reviews concluded that evidence for its efficacy is lacking.

Headaches

A joint statement of the German, Austrian, and Swiss headache societies and the German Society of Neurology recommends the use of paracetamol in combination with caffeine as one of several first line therapies for treatment of tension or migraine headache.In the treatment of acute migraine, it is superior to placebo, with 39% of people experiencing pain relief at 1 hour compared to 20% in the control group.

Postoperative pain

Paracetamol, when combined with NSAIDs, may be more effective for treating postoperative pain than either paracetamol alone or NSAIDs alone.

Packaging

25kg fiber drum or 25kg bag

11.2mt per 20ft container(drum package), 

17mt per 20ft container(bag package)