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Glimepiride (CAS No 93479-97-1), (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea,[1] or as second-generation.Practically insoluble in water, soluble in DMF, slightly soluble in methylene chloride & methanol.
Specification
Appearance White or almost white powder
Related substances, % Impurity A≤0.80
Impurity B ≤0.40
Impurity C ≤0.10
Impurity D ≤0.20
Any other impurity, % ≤0.10
Total impurities, % ≤0.50
Water, % ≤0.50
Heavy metals, % ≤0.001
Residue on ignition, % ≤0.20
Residual solvents, ppm Acetone ≤5000
Assay,% 98.00 ~ 102.00
Application
Glimepiride (Glimer) is indicated to treat type 2 diabetes mellitus; its mode of action is to increase insulin production by the pancreas. It is not used for type 1 diabetes because in type 1 diabetes the pancreas is not able to produce insulin.Its use is contraindicated in patients with hypersensitivity to glimepiride or other sulfonylureas, and during pregnancy.
Packaging&Storage
5kg per aluminium tin, or 25kg per fiber drum, or as per customer’s requirements.
Store in a well-closed container away from moisture.