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Flurbiprofen (CAS No 5104-49-4),  is a member of the phenylalkanoic acid derivative family of nonsteroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain. Side effects are analogous to those of ibuprofen.

It was derived from propionic acid by the research arm of Boots UK during the 1960s, a period which also included the discovery of ibuprofen, indometacin, diclofenac, naproxen, ketoprofen, and sulindac.

Specification

Characteristics             A White or almost white, crystallinepowder

Identification             A:IR;  B:UV

Melting range             114-117℃

Loss on drying             NMT0.5%

Residue on ignition     NMT0.1%

Heavy metals             NMT 0.001%

Related compounds

Impurity A                     NMT 0.5%

Individual impurity     NMT 0.2%

Total impurities             NMT1.0%

Assay                     99.0-100.5%

Application

1)Indications of efficacymainly. Used for rheumatoid arthritis. Suitable for relieving postoperative pain and various forms of cancer.

2)Chemical composition. The fluorine flurbiprofen.

3)Pharmacological.  This product is a non-steroidal anti-inflammatory drugs, formed in the body after intravenous flurbiprofen works. Its mechanism is similar to other non-steroidal anti-inflammatory drugs, by blocking prostaglandin biosynthesis and function. This products of analgesic role, by acetic acid induced of twisted test, and nandall-selatto test, and arthritis pain, animal (small rat, and big rat) model compared has its and o Republika horse forest lysine, and ketone ibuprofen and analgesic new of effectiveness, results this products effectiveness and muscle note analgesic new equal or slightly strong, than muscle note ketone ibuprofen or static note o Republika horse forest lysine strong, role continued time also long. The safety of this product on the formation of gastric ulcer index with these drugs is equal to or a little larger.

4) Drug interactions. It reduced the frusemide the diuretic effect, but enhance the anticoagulant of coumarin (warfarin). Similar compounds (fenbufen) quinolones and sharing, there are rare reports of convulsions.

Packaging&Storage

25 kg/drum.

Stored in cool and dry place. Keep away from strong heat and light.